Mar-Rizatriptan: Rizatriptan belongs to a class of medications known as 5-hydroxytryptamine agonists (also called triptans). depression, psychomotor impairment, serotonin syndrome (additive effects) Avoid ergotamine for 6 hr after almotriptan, sumatriptan, rizatriptan and zolmitriptan, and for 24 hr after eletriptan. Rizatriptan is not an inhibitor of the activities of human liver cytochrome P450 isoforms 3A4/5, 1A2, 2C9, 2C19, or 2E1; rizatriptan is a competitive inhibitor (K i =1400 nM) of cytochrome P450 2D6, but only at high, clinically irrelevant concentrations. You should not take this medicine if you have taken eletriptan, frovatriptan or naratriptan in the previous 24 hours. Caffeine. Grapefruit and grapefruit juice may interact with caffeine and ergotamine and lead to unwanted side effects. What Is Maxalt? Rizatriptan 10 mg tablet was compared with two ergotamine 1 mg/caffeine 100 mg tablets in a study of 439 patients.12. Teva-Rizatriptan ODT: Rizatriptan belongs to a class of medications known as 5-hydroxytryptamine agonists (also called triptans). A change in medication level, rather than a true interaction, occurs between propranolol (Inderal) and rizatriptan (Maxalt). Those drugs may include: Learn more about these and Ergotamine Tartrate/Caffeine interactions with other drugs. Maxalt is a prescribed medication that treats migraines. The pain of migraine headaches is thought to be caused by dilated blood vessels inside the head. The pain of migraine headaches is thought to be caused by dilated blood vessels inside the head. Drug interactions can be prevented by avoiding unwanted drug combinations. Drug interactions. Rizatriptan (Maxalt) Sumatriptan (Imitrex) Zolmitriptan (Zomig) Warfarin-- St. John's wort reduces the effectiveness of warfarin, an anticoagulant (blood-thinner). The pain of migraine headaches is thought to be caused by dilated blood vessels inside the head. Rizatriptan is a competitive inhibitor of cytochrome P450 2D6 but only at high, clinically irrelevant concentrations. What about melatonin interactions with more common substances? The regular tablet form is now available in generic and is fairly cheap. If you also take "triptan" migraine drugs (such as sumatriptan, rizatriptan), you will need to separate your triptan dose from your dose of this medication to lessen the chance of serious side effects. While Rizatriptan isn’t intended to prevent migraine headaches or reduce how often they occur, it can treat the symptoms of the migraine headache you do have. Increased clearance of caffeine by phenytoin. If it's a migraine it will likely resolve with sleep. ergotamine + isoniazid use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. Maxalt can help you cope with debilitating migraines and get […] It is taken by mouth. Caffeine belongs to the group of medications called stimulants. The half-life of rizatriptan averages 2—3 hours. Headache relief at 2 h was 75.9% for rizatriptan and 47.3% for ergotamine/caffeine (p < or = 0.001), with rizatriptan being superior to ergotamine/caffeine within 30 min of dosing. You should not take this medicine if you have taken any of the following triptan medicines in the previous six hours: almotriptan, rizatriptan, sumatriptan or zolmitriptan. Many important interactions for simvastatin (Zocor) and atorvastatin relate to drugs that inhibit or induce metabolism via the cytochrome P450 (CYP3A4) enzyme, or … Rizatriptan, sold under the brand name Maxalt among others, is a medication used for the treatment of migraine headaches. Rizatriptan comes as a tablet and an orally disintegrating tablet to take by mouth. Use within 24 hours is contraindicated. Maxalt (rizatriptan) is to stop migraines at the start of such a headache & has less success as such a pounding pain headache has gone on & on. 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