Gene mutations are responsible for causing the early fusion of the skull, hand and feet bones. Individuals with Apert syndrome typically have the following conditions: Apert Syndrome … - Supernumerary teeth. Purpose : Developing teeth are used to assess maturity and estimate age in a number of disciplines. Apert syndrome (AS) is an autosomal-dominant inherited disease characterized by premature fusion of bilateral coronal sutures, mid-facial hypoplasia, and symmetric syndactyly of hands and feet. METHODS: This retrospective study examined all Apert syndrome patients from four craniofacial centers who had a panoramic radiograph taken before the age of 16 years. - Shovel-shaped incisors. - Dental fusion. The purpose of this investigation was to study the dental maturation in children with Crouzon or Apert syndrome compared with nonsyndromic controls. - About a 1-year dental delay in maturation/eruption in primary and permanent teeth. Most cases are sporadic. Most children with Apert Syndrome have some degree of webbing between the fingers or toes. Chances of occurrence of Apert syndrome. The palate is often high and arched, and sometimes cleft palate occurs. Ankylosis of teeth Anodontia Apert syndrome Arthrogryposis multiplex congenita whistling face Arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay Atelosteogenesis type 1 Atelosteogenesis type 2 Atelosteogenesis type 3 Auriculo-condylar syndrome Dental problems caused by fusion of teeth sockets. Mutations in the gene encoding fibroblast growth factor receptor 2 (FGFR2), located on chromosome 10, account for almost all known cases . APERT SYNDROME. Successful treatment of patients with Apert syndrome requires an interdisciplinary medical team, including: … Knowledge of the most prevalent tooth agenesis patterns may increase our understanding of Apert syndrome by subphenotyping patients with regard to these patterns and by making genotype-phenotype correlations possible.In conclusion, in the present study, the subjects with Apert syndrome were found to exhibit a high prevalence of dental agenesis. Apert syndrome is a genetic disorder, characterized by deformities of the skull, face, and limbs affecting an individual’s health, daily function, and social interaction. There appears to be clinical observations indicating delayed eruption of the permanent teeth in the Apert child. Apert syndrome (acrocephalosyndactyly type I, MIM #101200) is an autosomal dominant disorder that occurs in 6 to 15.5 out of 1 million livebirths . Patients and Methods : Records of 40 children with … Table 1. Apert syndrome, also called acrocephalosyndactyly, is a genetic syndrome characterized by anomalies of the skull, face and limbs. Presence of extra finger or fusion of fingers. Hands and feet. A child with Apert syndrome also suffers from midface hypoplasia, bicoronal synostosis, and complex syndactyly of the arms and legs. The infant suffering from apert syndrome also suffers from heart, gastrointestinal and urinary problems. Palate. - Enamel opacities and/or hypoplasia. - Tooth agenesis. The mid-face has a sunken-in appearance, the upper jaw slopes backward, lower teeth project in front of the upper teeth. In midface hypoplasia the growth of the top portion of the face, around 2/3rd of it, is anomalous resulting in an unusual look, teeth problems and other illness like sleep apnea. Causes of Apert Syndrome Delayed development and short height. - Ectopic eruption of upper first permanent molars.